EMU Oil In Combination With Other Active Ingredients For Treating Skin Imperfections

ABSTRACT

Compositions comprising emu oil as a vehicle for the delivery of other active ingredients for the treatment of cosmetic and other skin imperfections such as acne, wrinkles, and hair loss are disclosed. Methods of treating cosmetic and other skin imperfections using the compositions are also disclosed.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional application, claiming priority to U.S.patent application Ser. No. 14/807,959 filed on Jul. 24, 2015, which isa divisional application claiming priority to U.S. patent applicationSer. No. 13/156,308 filed Jun. 8, 2011, which is now U.S. Pat. No.9,138,446.

BACKGROUND OF THE INVENTION

Emu oil has been used for hundreds of years by the native aborigines ofAustralia as a salve, because of its unique properties that allow it todeeply penetrate the epidermis. Studies have corroborated that Emu oilis non-comedogenic, has anti-inflammatory properties, is deeplymoisturizing, and deeply penetrating.

A variety of topical agents are used to treat various disorders, such asacne, wrinkles, and alopecia. It would be advantageous to havecompositions which increase the ability of these agents to penetrate theskin, so as to improve their activity. The present invention providessuch compositions, and methods for their use.

SUMMARY OF THE INVENTION

Compositions comprising various active and cosmetic ingredients in emuoil are disclosed, as well as methods of treating various disorders,including skin disorders, using the compositions. The compositionsinclude emu oil and various active ingredients to treat a variety ofskin diseases and imperfections. The compositions use the penetratingproperties of emu oil to augment the efficacy of the active and cosmeticingredients, resulting in an enhanced effect.

In various embodiments of the invention, the active ingredients include:

One or more of Doxycycline, Erythromycin, Salicylic Acid, SulphacetamideSodium, Retin-A, Retinols, Retinoids, Azelaic acid, Clindamycin,Tazarotene, and Benzoyl Peroxide for treating acne;

One or both of Finasteride and Minoxidil for treating hairloss/alopecia;

Steroid creams and lotions, such as hydrocortisone butyrate, fortreating various skin diseases that are commonly treated with steroids,including, but not limited to, psoriasis, atopic dermatitis, and contactdermatitis;

Retinol for wrinkles, and one or more of Acetyl Hexapeptide-3, AcetylGlutamyl Heptapeptide, Palmitoyl Pentapeptide-3, Palmitoyl Oligopeptide,Terapeptide-3 and Dimethylaminoethanol, which reportedly act throughstimulation of collagen and elastin as well as possessing anti-oxidantactivity, to provide firming and improve the overall health appearanceof the skin, and to remove wrinkles;

Glycolic acid for treating sun damage.

Alpha hydroxy acids, beta hydroxy acids and Kojic acid for exfoliatingthe skin and stimulating the cell production in the dermis, whichresults in a “plumper” thicker dermal layer by stimulating collagen andelastin production. This results in a smooth appearance of the skin aswell as elimination of fine lines and wrinkles. Through the exfoliationprocess they also work well to remove/decrease hyper-pigmentation, whichcan be hormonally or solar induced.

Green Tea as a pore size reducer, a hydrating agent, and ananti-oxidant.

Copper peptide for treating xerosis of the skin, removing scars, andproviding anti-oxidant properties.

Idebenone and Ubiquinone—which have antioxidant activity that helpsremove free radical damage and allows for the resumption of healthytissue regeneration.

Human growth hormone for replacement therapy, and increasing skin vigorand tone.

DETAILED DESCRIPTION

Emu oil is obtained from a large, approximately five feat tail,flightless bird of Australia known as an Emu, Dromideiusnovaehollandiae. Emus are fanned for their meat, which is low incholesterol and fat. The oil rendered from the Emu is actually asemi-solid fat (i.e., fat and oil mixture) at room temperature, but willherein be referred to as an oil.

The fat and oil mixture is stripped from the carcass of the Emu and canbe melted to further liquefy the oil. Emu oil obtained in this manner isyellow in color and is olfactorially offensive. It is possible, throughrefining processes well known to those of skill in the art, to removethe yellow color from the oil and reduce its odor. PCT/AU91/00517 refersto removing the yellow color from Emu oil by exposing it to sunlight,page 8, and by subjecting it to chemical oxidation by mixing it withbenzoyl peroxide in an organic solvent, page 9.

Emu Oil can be obtained from any commercial source such as TheScienceLab(above), EmuMagic (Nevis, Minn.), Wonder Oil Products, Inc (Middleton,Calif.), Uniquely Emu Products Inc (Ottawa, Ill.), etc. The activeingredients can be obtained from various suppliers, and mixed with EmuOil by simple vortexing. In the description below, all concentrationsare weight/weight of the additive to emu oil, unless otherwiseindicated.

Treatment of Skin Disorders

The compositions described herein can be used to treat acne and otherskin disorders, in particular, for use in the following therapeuticfields:

1) for treating dermatological conditions and afflictions linked to adisorder of keratinization involving differentiation and proliferation,in particular for treating acne vulgaris, comedonic or polymorphic acne,acne rosacea, nodulocystic acne, acne conglobata, senile acne, secondaryacnes, such as solar, drug or occupational acne, or hidradenitissuppurativa,

2) for treating other types of disorders of keratinization, inparticular ichthyoses, ichthyosiform conditions, Darier's disease,palmoplantar keratoderma, leukoplakia and leucoplakiform conditions, orcutaneous or mucosal (oral) lichen,

3) for treating other dermatological conditions linked to a disorder ofkeratinization with an inflammatory and/or immunoallergic component and,in particular, all forms of psoriasis, whether cutaneous, mucosal orungual, and even psoriatic rheumatism, or alternatively cutaneous atopy,such as eczema, or respiratory atopy or alternatively gingivalhypertrophy; the compounds can also be used in some inflammatoryconditions not exhibiting disorder of keratinization, such asfolliculitis,

4) for treating all dermal or epidermal proliferations, whether they arebenign or malignant and whether they are or are not of viral origin,such as common warts, flat warts, molluscum contagiosum andepidermodysplasia verruciformis, florid or oral papillomatoses, and theproliferations which can be induced by ultraviolet radiation, inparticular in the case of actinic keratoses,

5) for repairing or combating skin aging, whether photoinduced orchronologic, or for reducing pigmentations, or any pathology associatedwith chronologic or actinic aging;

6) for preventively or curatively treating disorders of cicatrization orskin ulcers, for preventing or repairing stretch marks, or alternativelyfor promoting cicatrization,

7) for combating disorders of the sebaceous function, such ashyperseborrhoea of acne or simple seborrhoea,

8) in the treatment of any condition of fungal origin on the skin, suchas tinea pedis and tinea versicolor,

9) in the treatment of dermatological conditions with an immunologicalcomponent,

10) in the treatment of skin disorders due to exposure to UV radiation.

The compositions according to the invention are particularly useful forthe preventive or curative treatment of acne vulgaris.

Treatment of Acne

When used to treat acne, the compositions can include an antibiotic,salicyclic acid and/or salicylates, benzoyl peroxide, and the like.

The salicylic acid or salicylates can be in the form of a naturalextract or as a pure compound. Examples of extracts that includesalicylates include willow bark and aspen bark.

Salicylic acid is a keratolytic agent; promotes desquamation, clearsblockages, helps prevent new lesions, & improves skin texture andhyperpigmentation after breakouts. The presence of salicylates alsohelps reduce the acidity of the salicylic acid, by providing a buffer.That is, when an acid (in this case, salicylic acid) and its conjugatebase (in this case, salicylates) are present in a formulation, eachbuffers the other, according to the well-known Henderson-Hasselbachequation (pH=pKa+log(concentration of acid/concentration of base).

Any cosmetically-acceptable salt of salicylic acid (i.e., salicylate)can be used in the formulations described herein. Representative saltsinclude, but are not limited to, salts with cations of ammonium, sodium,potassium, magnesium, calcium, strontium, barium, aluminum, iron, zinc,bismuth and organic amines. A salt with at least one of these cations ispreferable. More preferable is a sodium, potassium, magnesium or zincsalt, still more preferable is a sodium, potassium or zinc salt, andparticularly preferable is a sodium salt.

The salicylic acid can be obtained from various suppliers, such asParchem, USA, and the combination used to treat acne. Salicylic acid,typically in dry powder form, can be mixed with Emu Oil in aconcentration of about 2%. In use, the mixture is applied once or twicedaily on the acne lesion till resolution. In one embodiment, the activeingredient is doxycycline hyclate or doxycycline monohydrate, which canbe obtained from Mylan laboratories, and the combination is used totreat acne. The concentration of active ingredient in the Emu Oil rangesfrom about 1 mg to about 100 mg per 100 cc of Emu Oil. The mixtures areto be applied once or twice daily on the acne lesion till resolution. Inthis and other embodiments, resolution of the acne lesion will bereadily and visibly apparent to the patient to whom the composition isapplied.

In another embodiment, the active ingredient is erythromycin, which canbe obtained from various suppliers such as Abbott Labs, USA (EESGranules), and the combination is used to treat acne. Erythromycin,typically in dry powder form, can be mixed with Emu Oil in aconcentration of between about 1% and about 2% by weight. In use, themixture is applied once or twice daily on the acne lesion untilresolution.

Clindamycin can be obtained from suppliers such as Dermik, USA. Thepowder is mixed with Emu Oil in a concentration of 10 mg/100 ml. Themixture is to be applied once or twice daily on the acne lesion tillresolution.

In yet another embodiment, the active ingredient is sulphacetamidesodium, which can be obtained from suppliers such Shreejee Pharma,India. The sulphacetamide sodium, typically in dry powder form, is mixedwith Emu Oil in a concentration of about 10%. The mixtures are appliedonce or twice daily on the acne lesion till resolution.

In yet another embodiment, the active ingredient is tretinoin, which canbe obtained from suppliers such as Lozada Enterprises, USA. Thetretinoin is typically supplied in cream form, and the cream is mixedwith Emu Oil in a concentration of about 0.025% to about 0.1%. Themixture is applied once or twice daily on the acne lesion tillresolution.

In yet another embodiment, the active ingredient is azelaic acid, whichcan be obtained from suppliers such as Triveni Chemicals, India. Theazelaic acid, typically in the form of a powder, is mixed with Emu Oilin a concentration of around 20%. The mixture is applied once or twicedaily on the acne lesion till resolution.

Tazarotene can be obtained from suppliers such as Aurochem laboratories,India. The powder is mixed with Emu Oil in a concentration of 0.05-0.1%.The mixture is to be applied once or twice daily on the acne lesion tillresolution

Benzoyl Peroxide can be obtained from suppliers such as. Alfa Aesar,USA. The powder is mixed with Emu Oil in a concentration of betweenabout 2.5 to about 10%. The mixture is to be applied once or twice dailyon the acne lesion till resolution.

Other representative anti-acne agents that can be used, in addition tothe salicylic acid and salicylates, include sulfur, resorcinol, andresorcinol monoacetate. When present, sulfur is typically in an amountof between 0.1 and 10.0% w/w; resorcinol is typically in an amount ofbetween 0.1 and 2.0% w/w, and resorcinol monoacetate is typically in anamount of between 0.1 and 3.0% w/w.

Treatment of Hair Loss/Alopecia/Baldness

When used to treat hair loss, including alopecia and baldness, thecompositions commonly include emu oil and one or more of Finasteride andMinoxidil.

Finasteride can be obtained from suppliers such as Cygnus HealthcareSpecialties, India. The powder is mixed with Emu Oil in a concentrationranging from about 50 mg to about 100 mg per 100 ml Emu Oil. Thecombination is applied once or twice daily to area of hair loss on achronic basis.

Minoxidil Sulphate can be obtained from suppliers such as Loy PharmalabIncorporated, UK. The powder is mixed with Emu Oil in a concentrationranging from 2% to 5%. The combination is applied once or twice daily toarea of hair loss on a chronic basis.

Treatment of Psoriasis, Atopic Dermatitis, and Contact Dermatitis

Steroid creams and lotions can be obtained from many manufacturers. Forexample, Hydrocortisone 17-butyrate can be obtained from ArrowChemicals, USA. Hydrocortisone butyrate is mixed with Emu Oil to give aconcentration of 0.1%. It is applied locally to the skin lesion twice orthree times a day for the treatment of various skin diseases includingbut not limited to psoriasis, atopic dermatitis, and contact dermatitis.

Treatment of Wrinkles

All Trans Retinol and Retinyl palmitate can be obtained from supplierssuch as Paradise Marketing Group, US. The ingredients are mixed with EmuOil for a final concentration ranging from 1-2% The combination isapplied once or twice daily to wrinkles till satisfactory results arenoted.

Acetyl Hexapeptide-3 can be obtained from Lipotec, Spain. The peptide isdissolved in Emu Oil in concentration of 10%. The combination is appliedonce or twice daily for decreasing wrinkles.

Acetyl Glutamyl Heptapeptide can be obtained from Creative Peptides, US.The peptide is dissolved in Emu Oil in concentration of 10%. Thecombination is applied once or twice daily for decreasing wrinkles.

Palmitoyl Pentapeptide-3 can be obtained from Creative Peptides, US. Thepeptide is dissolved in Emu Oil in concentration of 10%. The combinationis applied once or twice daily for decreasing wrinkles.

Palmitoyl Oligopeptide can be obtained from Creative Peptides, US. Thepeptide is dissolved in Emu Oil in concentration of 3-4%. Thecombination is applied once or twice daily for decreasing wrinkles.

Palmitoyl Terapeptide-3 can be obtained from Creative Peptides, US. Thepeptide is dissolved in Emu Oil in concentration of 3-4%. Thecombination is applied once or twice daily for decreasing wrinkles.

Dimethylaminoethanol (DMAE) can be obtained from MD Cosmetics, US. DMAEis dissolved in Emu Oil in concentration of 3%. The combination isapplied once or twice daily for decreasing wrinkles.

Idebenone can be obtained from Mahalaxmi Chemi-Pharm, India. DMAE isdissolved in Emu Oil in concentration of 0.5%. The combination isapplied once or twice daily for decreasing wrinkles.

Ubiquinone can be obtained from WN Pharmaceuticals, Canada. Ubiquinoneis dissolved in Emu Oil in concentration of 1-3%. The combination isapplied once or twice daily for decreasing wrinkles.

Treatment of Sun Damage and/or Improvement of Skin Texture

Glycolic Acid can be obtained from suppliers such as Parchem, US. Thepowder is mixed with Emu Oil for a final concentration ranging from 10%to 80%. The combination is applied once daily to repair sun damage andimprove skin texture till satisfactory results are obtained.

Alpha Hydroxy Acids (AHA) can be obtained from suppliers such as InspireExports, India. Common AHA include lactic acid, malic acid, citric acid,and tartaric acid. Each powder is mixed with Emu Oil for a finalconcentration of 12% while keeping pH at 4.5-5.5 using adjusting basessuch as sodium hydroxide and hydrochloric acid. More than on AHA is notto be used in combination. The combination is applied once daily toimprove skin texture till satisfactory results are obtained. It works byexfoliating the skin and stimulating the cell production in the dermiswhich results in a “plumper” thicker dermal layer by stimulatingcollagen and elastin production. This results in a smooth appearance ofthe skin as well as elimination of fine lines and wrinkles. Through theexfoliation process they also work well to remove/decreasehyper-pigmentation which can be hormonally or solar induced.

Beta Hydroxy Acid or Salicylic acid can be obtained from suppliers suchas Suntran Industrial Group, Hong Kong. The powder is mixed with Emu Oilfor a final concentration of 1-2% while keeping pH at 3-4 usingadjusting bases such as sodium hydroxide and hydrochloric acid. Thecombination is applied once daily to improve skin texture tillsatisfactory results are obtained. It works by exfoliating the skin andstimulating the cell production in the dermis which results in a“plumper” thicker dermal layer by stimulating collagen and elastinproduction. This results in a smooth appearance of the skin as well aselimination of fine lines and wrinkles. Through the exfoliation processthey also work well to remove/decrease hyper-pigmentation which can behormonally or solar induced.

Kojic acid can be obtained from suppliers such as Parchem, USA. Thepowder is mixed with Emu Oil for a final concentration of 4%. Thecombination is applied once daily to improve skin texture tillsatisfactory results are obtained. It works by exfoliating the skin andstimulating the cell production in the dermis which results in a“plumper” thicker dermal layer by stimulating collagen and elastinproduction. This results in a smooth appearance of the skin as well aselimination of fine lines and wrinkles. Through the exfoliation processthey also work well to remove/decrease hyper-pigmentation which can behormonally or solar induced.

Green Tea can be obtained from suppliers such as Dermaxime, SouthAfrica. The dried extract is mixed with Emu Oil for a finalconcentration of 10%. The combination is applied once daily to improveskin texture till satisfactory results are obtained as a hydrating agentas well as an anti-oxidant.

UV Protection

When used to treat sun damage, the compositions can further includesunscreen and/or sunblocking agents. The term “sunscreen agent” as usedherein defines ultraviolet ray-blocking compounds exhibiting absorptionwithin the wavelength region between about 290 and about 400 nm.

The formulation can include, as sunblocking agents, one or more of zincoxide and titanium dioxide, and, most preferably, a combination of thesetwo agents. The range of these ingredients in the formulations istypically between about 8.10 and about 35.00 weight percent for titaniumdioxide, and between about 10 and about 25.65 weight percent for zincoxide.

Zinc oxide and titanium dioxide are mineral pigments often used forphotoprotection, as they are opaque to both UVA and UVB radiation.Although both provide opacity to UV light, titanium dioxide provides 3to 4 times better coverage and photoprotection. Titanium dioxide is aphysical sunscreen providing covering power and UV protection Zinc oxideis a physical sunscreen that provides covering power and UV protection;reduces sebum production, may promote wound healing, and has powerfulantioxidant activity Zinc oxide also provides additional benefits beyondUV protection Zinc is a component of at least 70 metalloenzymes and isalso needed in protein, DNA, and RNA synthesis. In addition, it is acofactor for Superoxide Dismutase (SOD), an enzyme providing crucialantioxidant activity and alleviating oxidative stress in cells Zincoxide is classified as a Category 1 skin protectant, providesantimicrobial activity, and is thought to be implicated in reducingsebum production and promoting wound healing.

Utilizing a combination of these two compounds will provide ample UVprotection, while also supplementing acne treatment and improving skincondition.

Ideally, the particle sizes of these agents are in the micron size orless. Microparticulate (also known as microfine) zinc oxide and titaniumdioxide are particulate sunscreen ingredients that absorb broad-spectrumultraviolet (UV) irradiation.

Treatment of Xerosis and/or Reduction of Scarring

Copper peptide or (Glycine-Histine-Lysine)2-Cu can be obtained fromCreative Peptides, US. The peptide is dissolved in Emu Oil inconcentration of 10%. The combination is applied once or twice daily forxerosis of the skin, reducing scars, and as an antioxidant.

Skin Rejuvenation and Replacement

Human growth hormone lotion can be used for replacement therapy and forskin rejuvenation at a concentration of 2.5 IU/L. HGH can be obtainedfrom Ferring Pharmaceuticals, US. It is applied topically once in themorning every day chronically as a replacement therapy.

Optional Components

The formulation can also include, in addition to these agents, othercosmetic, dermatological, and pharmaceutical active agents, including,but are not limited to: antioxidants; free radical scavengers;depigmentation agents; reflectants; antimicrobial (e.g., antibacterial)agents; allergy inhibitors; anti-aging agents; anti-wrinkling agents,antiseptics; analgesics; anti-inflammatory agents; fresheners; healingagents; anti infectives; inflammation inhibitors; vasoconstrictors;vasodilators; wound healing promoters; peptides, polypeptides andproteins; skin lightening agents; antifungals; counterirritants; make-uppreparations; vitamins; amino acids and their derivatives; herbalextracts; flavoids; sensory markers (i.e., cooling agents, heatingagents, etc.); skin conditioners; chelating agents; cell turnoverenhancers; nourishing agents; moisture absorbers; sebum absorbers andthe like; skin penetration enhancers; and other active ingredients.Other ingredients can include: Water (purified), PEG-4, Aloe barbadensisleaf juice, Allium cepa (onion) bulb extract, xanthan gum, allantoin,methylparaben, sorbic acid, and fragrance.

Fragrances and Sensory Markers

The formulation described herein also provides synchronizing the releaseof the sensory markers such as fragrances, flavors, cooling agents, suchas menthol derivatives, and heating agents, such as capsaicin. Therelease of the sensory markers can be used to convey to the consumer theproduct performance, provide long lasting odor or flavor perception, andsignal that a new application of the product is needed.

Conventional fragrance ingredients and perfume ingredients can be usedin the release system of the present invention. Selection of any perfumecomponent, or amount of perfume, is based on functional and aestheticconsiderations. Examples of usable fragrance and flavor compoundsdiscussed hereinafter, along with their odor characters, and theirphysical and chemical properties, are given in “Perfume and FlavorChemicals (Aroma Chemicals)”, Steffen Arctander, published by theauthor, 1969, and in “Common Fragrance and flavor Materials—Preparation,Properties and Uses”, Kurt Bauer and Dorotea Garbe, published by VCHVerlagsgesellschaft mbH, 1985, incorporated herein by reference.

Botanical extracts are oak bark extract, walnut extract, tincture ofarnica, hamamelis extract, ribwort extract, pansy extract, thyme or sageextract; for the treatment of damaged or injured skin, for example, St.John's wort tincture, cone flowers tincture, chamomile flowers extract,or calendula flowers tincture; and for the care of exhausted and damagedskin, for example, birch leaves extract, nettle extract, coldsfootextract, comfrey tincture, horsetail extract, or aloe vera extract.Vegetable preparations may also be released from the film layer for theintradermal treatment of diseases, for example, extracts of horsechestnut and butcher's broom in case of vein diseases, or extracts andtinctures of arnica, calendula, and capsicum in case of contusions,distortions, or haemorrhages. Vegetable preparations in the systemaccording to the present invention may also be used in transdermaltherapy, for example, ginseng extract in case of geriatric complaints;valerian tincture, extracts of melissa and hop to cause a sedativeeffect in case of superexcitation, sleep disturbances, and stress;extracts of kola and tea to achieve a stimulative effect; or hawthornextract to stabilize the circulatory system.

Preservatives

Preservatives can desirably be incorporated into the formulationsdescribed herein to protect against the growth of potentially harmfulmicroorganisms. While microorganisms tend to grow in the aqueous phase,microorganisms can also reside in the anhydrous or oil phase. As such,preservatives which have solubility in both water and oil are preferablyemployed in the present compositions. Suitable preservatives forcompositions of the present invention are alkyl esters ofpara-hydroxybenzoic acid. Other preservatives, which can be used includehydantoin derivatives, propionate salts, and a variety of quaternaryammonium compounds.

Appropriate preservatives can be selected to satisfy the preservativechallenge test and to provide product stability. Particularly preferredpreservatives are methylparaben, imidazolidinyl urea, sodiumdehydroacetate, propylparaben, trisodium ethylenediamine tetraacetate(EDTA), and benzyl alcohol. The preservative can be selected based onthe consideration of possible incompatibilities between the preservativeand other ingredients in the release system.

Preservatives are preferably employed in amounts ranging from about0.01% to about 2% by weight of the composition.

Vitamins

Various vitamins can be included in the formulations described herein.For example, vitamin A and derivatives thereof, vitamin B2, biotin,pantothenic acid, vitamin K, vitamin D, vitamin E and mixtures thereofcan be used.

Antimicrobial and Antifungal Actives

Antimicrobial and antifungal actives can be effective to prevent theproliferation and growth of bacteria and fungi and can be used in theformulations described herein. Non-limiting examples of antimicrobialand antifungal actives include beta-lactam drugs, quinolone drugs,ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin,2,4,4′-trichloro-2′-hydroxy diphenyl ether, 3,4,4′-trichlorobanilide,phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline,capreomycin, chlorhexidine, chlortetracycline, oxytetracycline,clindamycin, ethambutol, hexamidine isethionate, metronidazole,pentamidine, gentamicin, kanamycin, lineomycin, methacycline,methenamine, minocycline, neomycin, netilmicin, paromomycin,streptomycin, tobramycin, miconazole, tetracycline hydrochloride,erythromycin, zinc erythromycin, erythromycin estolate, erythromycinstearate, amikacin sulfate, doxycycline hydrochloride, capreomycinsulfate, chlorhexidine gluconate, chlorhexidine hydrochloride,chlortetracycline hydrochloride, oxytetracycline hydrochloride,clindamycin hydrochloride, ethambutol hydrochloride, metronidazolehydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycinsulfate, lineomycin hydrochloride, methacycline hydrochloride,methenamine hippurate, methenamine mandelate, minocycline hydrochloride,neomycin sulfate, netilmicin sulfate, paromomycin sulfate, streptomycinsulfate, tobramycin sulfate, miconazole hydrochloride, amanfadinehydrochloride, amanfadine sulfate, octopirox, parachlorometa xylenol,nystatin, tolnaftate, zinc pyrithione; clotrimazole; alantolactone;isoalantolactone; alkanet extract (alaninin); anise; arnica extract(helenalin acetate and 11, 13 dihydrohelenalin); Aspidium extract(phloro, lucinol containing extract); barberry extract (berberinechloride); bay sweet extract; bayberry bark extract (myricitrin);benzalkonium chloride; benzethonium chloride; benzoic acid and itssalts; benzoin; benzyl alcohol; blessed thistle; bletilla tuber;bloodroot; bois de rose oil; burdock; butyl paraben; cade oil; CAE(available from Ajinomoto, located in Teaneck, N.J.); cajeput oil;Cangzhu; capsicum frutescens extract; caraway oil; cascarilla bark (soldunder the tradename ESSENTIAL OIL); cedarleaf oil; chamomille;chaparral; chlorhexidine gluconate; chlorophenesin; chlorxylenol;cinnamon oil; citronella oil; clove oil; Crinipan AD (available fromClimbazole); 2,3-dihydro-farnesol; dehydroacetic acid and its salts;dill seed oil; DOWICIL 200 (available from Dow Chemical, located inMidland, Mich.); echinacea; elenolic acid; epimedium; ethyl paraben;Fo-Ti; galbanum; garden bumet; GERMALL 115 and GERMALL II (availablefrom ISP-Sutton Labs, located in Wayne, N.J.); German chamomile oil;giant knotweed; GLYDANT (available from Lonza, located in Fairlawn,N.J.); GLYDANT PLUS (available from Lonza); grapefruit seed oil; 1,6hexanediol; hexamidine diisethionate; hinokitiol; honey; honeysuckleflower; hops; immortelle; iodopropynl butyl carbamide (available fromLonza); isobutyl paraben; isopropyl paraben; JM ACTICARE (available fromMicrobial Systems International, located in Nottingham, NG); juniperberries; KATHON CG (available from Rohm and Haas, located inPhiladelphia, Pa.); kojic acid; labdanum; lavender; lemon balm oil;lemon grass; methyl paraben; mint; mume; mustard; myrrh; neem seed oil;ortho phenyl phenol; olive leaf extract (available from Bio Botanica);parsley; patchouly oil; peony root; 1,2 pentandiol; PHENONIP (availablefrom Nipa Labs, located in Wilmington, Del.); phenoxyethanol;phytosphingosine; pine needle oil; PLANSERVATIVE (available from CampoResearch); propyl paraben; purslane; quillaira; rhubarb; rose geraniumoil; rosemary; sage; salicylic acid; sassafras; savory; sichuan lovage;sodium meta bisulfate; sodium sulfite; SOPHOLIANCE (available fromSoliance, located in Compiegne, France); sorbic acid and its salts;sphingosine; stevia; storax; sucrose esters; tarmic acid; tea; tea treeoil (cajeput oil); thyme; triclosan; triclocarban; tropolone;turpentine; umbelliferone (antifungal); yucca; and mixtures thereof.

Anti-Inflammatory Agents

Anti-inflammatories can be included in formulations described herein toenhance photoprotection benefits, particularly from UVA.

Suitable steroidal anti-inflammatories include hydrocortisone;non-steroidal anti-inflammatories such as oxicans, salicylates, aceticacid derivatives, fenamates, propionic acid derivatives, pyrazoles,substituted phenyl compounds, 2-naphthyl containing compounds, andnatural anti-inflammatories such as aloe vera. Examples ofanti-inflammatories are described in U.S. Pat. No. 5,487,884, the entirecontents of which are incorporated herein by reference.

Anti-Wrinkle, Anti-Skin Atrophy and Skin Repair Actives

Anti-wrinkle, anti-skin atrophy and skin repair actives can be effectivein replenishing or rejuvenating the epidermal layer and can be includedin formulations described herein. These actives generally provide thesedesirable skin care benefits by promoting or maintaining the naturalprocess of desquamation.

Nonlimiting examples of anti-wrinkle and anti-skin atrophy activesinclude vitamin B3 compounds (such as niacinamide and nicotinic acid),salicylic acid and derivatives thereof (such as 5-octanoyl salicylicacid, heptyloxy 4 salicylic acid, and 4-methoxy salicylic acid);sulfur-containing D and L amino acids and their derivatives and salts,particularly the N-acetyl derivatives, a preferred example of which isN-acetyl-L-cysteine; thiols, e.g. ethane thiol; hydroxy acids, phyticacid, lipoic acid; lysophosphatidic acid; skin peel agents (e.g., phenoland the like); Actein 27-Deoxyactein Cimicifugoside (available fromCirnigoside); adapalene; ademethionine; adenosine; aletris extract;alkyl glutathione esters; alkoxyalkoxy alkoxyn benzoic and derivatives;aloe derived lectins; amino propane phosphoric acid; 3-aminopropyldihydrogen phosphate; Amadorine (available from Barnet Products); aniseextracts; AOSINE (available from Secma); arginine amino benzoate; ASCIII (available from E. Merck, located in Darmstadt, Germany); ascorbicacid; ascorbyl palmitate; asiatic acid; asiaticosides; ARLAMOL GEO™(available from ICI, located in Wilmington, Del.); azaleic acid; benzoicacid derivatives; bertholletia extracts; betulinic acid; BIOCHANIN A ANDBIOPEPTIDE CL (available from Sederma, located in Brooklyn, N.Y.);BIOPEPTIDE EL (available from Sederma); biotin; blackberry bark extract;blackberry lily extracts; black cohosh extract; blue cohesh extract;butanoyl betulinic acid; carboxymethyl 1,3 beta glucan; catecholamines;chalcones; citric acid esters; chaste tree extract; clover extracts;coumestrol; CPC Peptide (available from Barnet Products); daidzein; danggui extract; darutoside; debromo laurinterol;1-decanoyl-glycero-phosphonic acid; dehydrocholesterol;dehydrodicreosol; dehydrodieugenol; dehydroepiandersterone; DERMOLECTINE(available from Sederma); dehydroascorbic acid; dehydroepiandersteronesulfate; dianethole; hydroxy benzoic acid; 2,4 dihydroxybenzoic acid;diglycol guanidine succinate; diosgenin; disodium ascorbyl phosphate;dodecanedioic acid; Ederline (available from Seporga); Enderline(available from Laboratories Seporga); equol; eriodictyol; estrogen andits derivatives; ETF (available from Laboratories Seporga); ethocyn;ELESERYL SH (available from Laboratories Serobiologiques, located inSomerville, N.J.); ENDONUCLEINE (available from LaboratoriesSerobiologiques); ergosterol; eythrobic acid; fennel extract; fenugreekseed extract; FIBRASTIL (available from Sederma); FIBROSTIMULINES S andP (available from Sederma); FIRMOGEN LS 8445 (available fromLaboratories Serobiologiques); formononetin; forsythia fruit extract;gallic acid esters; gamma amino butyric acid; GATULINE RC (availablefrom Gattlefosse, located in Priest, France); genistein; genisteine;genistic acid; gentisyl alcohol; gingko bilboa extracts; ginsengextracts; ginsenoside (RO, R61, R62, R63, Rc, RD, RE, RF, RF-2, RG-I,RG-2); gluco pyranosyl-L-ascorbate; glutathione and its esters;glycitein; hesperitin; hexahydro curcumin; HMG-coenzyme A reductaseinhibitors; hops extracts; 11 hydroxy undecanoic acid; 10 hydroxydecanoic acid; 25-hydroxycholesterol; 7-hydroxylated sterols;hydroxyethyl isostearyloxy isopropanolamine; hydroxy-tetra methylpiperidinyloxy; hypotaurine; ibukijakou extract; isoflavone SG 10(available from Barnet Products); kinetin; kohki extract;L-2-OXO-thiazolidine-4-carboxylic acid esters; lactate dehydrogenaseinhibitors; 1-lauryl,-lyso-phosphatidyl choline; lectins; lichochalconeLF15 (available from Maruzen); licorice extracts; lignan; lumisterol;lupenes; luteolin; lysophosphitidic acid; magnesium ascorbyl phosphate;margin; melatonin; melibiose; metalloproteinase inhibitors; methoprene;methoprenic acid; mevalonic acid; MPC COMPLEX (available from CLR); Nmethyl serine; N methyl taurine; N,N1-bis(lactyl) cysteamin; naringenin;neotigogenin; o-desmethylangoiensin; oat beta glucan; oleanolic acid;pantethine; phenylalanine; photoanethone; piperidine; placentalextracts; pratensein; pregnenolone; pregnenolone acetate; pregnenolonesuccinate; premarin; quillaic acid; raloxifene; REPAIR FACTOR 1 andREPAIR FACTOR FCP (both available from Sederna); retinoates (esters ofC2.sub.-20 alcohols); retinyl glucuronate; retinyl linoleate;S-carboxymethyl cysteine; SEANAMINE FP (available from LaboratoriesSerobiologiques); sodium ascorbyl phosphate; soya extracts; spleenextracts; tachysterol; taurine; tazarotene; tempol; thymulen; thymusextracts; thyroid hormones; tigogenin; tocopheryl retinoate; toxifolin;traumatic acid; tricholine citrate; trifoside; uracil derivatives;ursolic acid; vitamin D3 and its analogs; vitamin K; vitex extract; yamextract; yamogenin; zeatin; and mixtures thereof.

Skin Barrier Repair Actives

Skin barrier repair actives are those skin care actives which can helprepair and replenish the natural moisture barrier function of theepidermis and can be included in formulations described herein.Non-limiting examples of skin barrier repair actives include Alpha Lipid(available from Lucas Meyer); ascorbic acid; biotin; biotin esters;brassicasterol; caffeine; campesterol; canola derived sterols;Cennamides (available from Ennagram); Ceramax (available from AlbanMuller); CERAMAX (available from Quest, located in Ashford, England);CERAMIDE 2 and CERAMIDE H03™. (both available from Sederma); CERAMIDE 11(available from Quest); CERAMIDE III and IIIB (both available fromCosmoferm, located in Deft, Netherlands); CERAMIDE LS 3773 (availablefrom Laboratories Serobiologiques); CERAMINOL (available from Inocosm);Cerasol and Cephalip (both available from Pentapharm); cholesterol;cholesterol hydroxystearate; cholesterol isostearate; 7dehydrocholesterol; DERMATEIN BRC and DERMATEIN GSL (both available fromHormel); ELDEW CL 301 AND ELDEW PS 203 (both available from Ajinomoto);Fitobroside (available from Pentapharm); galactocerebrosides; Generol122 (available from Henkel); glyceryl serine amide; hydroxyethylisostearyl isopropanolamine; lactic acid; Lactomide (available fromPentapharm); lanolin; lanolin alcohols; lanosterol; lauric acid Nlaurylglucamide; lipoic acid; N-acetyl cysteine; N-acetyl-L-serine;N-methyl-L-Serine; Net Sterol-ISO (available from Barnet Products);vitamin B.sub.3 compounds (such as niacinamide and nicotinic acid);palmitic acid; panthenol; panthetine; phosphodiesterase inhibitors;PHYTO/CER (available from Intergen); phytoglycolipid millet extract(available from Barnet Products Distributer, located in Englewood,N.J.); PHYTOSPHINGOSINE (available from Gist Brocades, located in Kingof Prussia, Pa.); PSENDOFILAGGRIN (available from Brooks Industries,located in South Plainfield, N.J.); QUESTAMIDE H (available from Quest);serine; sigmasterol; sitosterol; soybean derived sterols; sphingosine;sphingomylinase; S-lactoyl glutathione; stearic acid; Structurine(available from Silah); SUPER STEROL ESTERS (available from Croda);thioctic acid; THSC CERAMIDE OIL (available from Campo Research);trimethyl glycine; tocopheryl nicotinate; vitamin D.sub.3; Y2 (availablefrom Ocean Pharmaceutical); and mixtures thereof.

Non-Steroidal Cosmetic Soothing Actives

Cosmetic soothing actives can be effective in preventing or treatinginflammation of the skin and can be included in the formulationsdescribed herein. The soothing active enhances the skin appearancebenefits of the present invention, e.g., such agents contribute to amore uniform and acceptable skin tone or color.

The exact amount of anti-inflammatory agent to be used in thecompositions will depend on the particular anti-inflammatory agentutilized since such agents vary widely in potency.

Non-limiting examples of cosmetic soothing agents include the followingcategories: propionic acid derivatives; acetic acid derivatives; fenamicacid derivatives; biphenylcarboxylic acid derivatives; and oxicams. Allof these cosmetic soothing actives are fully described in U.S. Pat. No.4,985,459 to Sunshine et al., issued Jan. 15, 1991, incorporated byreference herein in its entirety. Non-limiting examples of usefulcosmetic soothing actives include acetyl salicylic acid, ibuprofen,naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen,indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen,tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen,bucloxic acid, absinthium, acacia, ACTIGEN Y (available from ActiveOrganics), aescin, agrimony, alder buckthorn extract, allantoin, aloe,angelica, APT (available from Centerchem), arnica, astragalus,astragalus root extract, AVOCADIN HS-80 (available from Croda), avocado,azulene, Baicalin SR 15 (available from Barnet Products Dist.), baikalskullcap, baizhu, balm mint, balm of gilead, balsam canada, barley malt,basil, bayberry fruit, bee pollen, bladderwrack, BIODYNES TRF (availablefrom Arch Personal Care), BIOPHYTEX (available from LaboratoriesSerobiologiques), bisabolol, black cohosh, black cohosh extract bluecohosh, blue cohosh extract, blue flag, boneset, borage, borage oil,bradykinin antagonists, bromelain, burdock root, butterbur, calendula,calendula extract, Canadian Willowbark Extract (available from Fytokem),candelilla wax, Cangzhu, canola phytosterols, capsicum,carboxypeptidase, celery seed, celery stem extract, CENTAURIUM(available from Sederma), centaury extract, chamazulene, chamomile,chamomile extract, chaparral, chaste tree, chaste tree extract,chickweed, chicory root, chicory root extract, chirata, chishao,collodial oatmeal, coltsfoot, comfrey, comfrey extract, coneflower,cornflower, CROMOIST CM GLUCAN (available from Croda), CYTOBIOL IRIS A(available from Gattefosse), darutoside, dehurian angelica, devil'sclaw, divalent metals (such as, magnesium, strontium, and manganese),doggrass, dogwood, dong quai, Eashave (available from Pentapharm),eleuthero, ELHIBIN (available from Pentapharm), ENTELINE 2 (availablefrom Secma), ephedra, epimedium, esculoside; ethacrynic acid, eveningprimrose, eyebright, Extract LE-100 (available from Sino Lion),Fangfeng, fennel seed extract, feverfew, ficin, fir needle, forsythiafruit, Fytosterol 85 (available from Fytokem), ganoderma, gaoben,gardenia, Gatuline A (available from Gattefosse), gentian, germaniumextract, gingko bilboa extract, ginkgo, ginseng extract, GIVOBIO GZn(available from Seppic), goldenseal, gorgonian extract, gotu kola, grapefruit extract, guaiac wood oil, guggal extract, helenalin esters, henna,honeysuckle flower, hops, horehound extract, horsechestnut, horsetail,huzhang, hypericum, Iceland moss, ichthyol, immortelle, ipecac,IRICALMIN (available from Pentapharm), irish moss, ivy, Japanese greentea, job's tears, jojoba, jujube, juniper berry, kava kava, kiwi, kolaextract, kumquat, LANACHRYS 28 (available from Lana Tech), lemon oil,LEMON SECRETS (available from Gattefosse), lianqiao, licorice root,ligusticum, ligustrum, lime flower, linden, lovage root, luffa, mace,magnolia flower, mandarin orange, manjistha extract, margaspidin,marshmallow, matricin, meadowsweet, melatonin, MICROAT IRC (availablefrom Nurture), mints, mistletoe, Modulene (available from Seporga), monoor diglucosides of glabridin, mono or diglucosides of gentisin, MTA(5′-deoxy-5′-methylhioadenosine), mulberry bark, mullein, mung beanextract, musk, myrrh, N-methyl arginine, nettle, neutral henna, oakbark, oat beta glucan, oat extract, orange, orange blossom, panthenol,papain, papaya, parsley, passion fruit, pear, periwinkle, pine cone,phenoxyacetic acid, peony bark, peony root, Phytoplenolin (availablefrom Bio Botanica), phytosphingosine, plankton, Preregen (available fromPentapharm), prickly ash bark, purslane, QUENCH T (available fromCenterchem), quillaia, red clover blossom, red sage, rehmannia, rhubarb,rice bran, roman chamomile, rose, rosemary, rosmarinic acid, royaljelly, rue, rutin, sandlewood, sanqi, sarsaparilla, saw palmetto,SENSILINE (available from Silab), SEPICALM S (available from Seppic),SEPICALM VG (available from Seppic), SIEGESBECKIA (available fromSederma), skullcap, slippery elm, soap bark, spearmint, SPHINGANINE(available from Croda), stearyl glycyrrhetinate, Stimutex (availablefrom Pentapharm), storax, strontium nitrate, sweet birch oil, sweetwoodniff, tagetes, tea extract, thyme extract, tienchi ginseng,tocopherol, tocopheryl acetate, triclosan, turmeric, urimei, ursolicacid, VEDACALM (available from Gattefosse), violet, white lily, whitepine bark, wild cherry bark, witch hazel, yarrow, yeast extract, yucca,and mixtures thereof.

Anti-Itch Ingredients

Also useful as active ingredients in the present invention are anti-itchingredients.

Non-limiting examples of anti-itch ingredients which are useful in thecompositions of the present invention are those selected from the groupconsisting of aloe vera, balm of gilead, beet, pennyroyal, peppermint,soapwort, Stimu-tex (available from Pentapharm); Takanal (available fromIkeda-Distributer); Ichthyol (available from InternationalSourcing-Distributor); Oxygenated Glyceryl Triesters (available fromSeporgia) and mixtures thereof.

Antioxidants

Representative antioxidants include vitamin E, tocopheryl acetate,betaglucan, coenzyme Q10, butylated hydroxy toluene (BHT), butylatedhydroxy anisole (BHA), superoxide dismutase, propylgallate, and thelike.

The invention can be further illustrated by the following examples ofpreferred embodiments thereof, although it will be understood that theseexamples are included merely for purposes of illustration and are notintended to limit the scope of the invention unless otherwisespecifically indicated. All percentages, ratios, and parts herein, inthe Specification, Examples, and Claims, are by weight and areapproximations unless otherwise stated.

EXAMPLE 1 Anti-Acne Treatment

A study conducted with Emu Oil and doxycycline was undertaken involunteers with mild to moderate acne. Sixteen volunteers participatedwho had mild to moderate acne, and one had severe cystic acne. Within 48hours of application of the combination, the acne had disappeared. Onlythe volunteer with severe cystic acne had to apply the combination forfive days for the acne to resolve. The efficacy was 100%. This wassuperior to Emu Oil alone since Emu Oil did not show similar efficacy(rate less than 50%, time to effect a week or longer, and not effectivein cystic acne). There are no tropical formulations of doxycycline tocompare with. On histological examination, doxycycline was found in thedermis within 15 minutes of topical application.

While the foregoing specification teaches the principles of the presentinvention, with examples provided for the purpose of illustration, itwill be understood that the practice of the invention encompasses all ofthe usual variations, adaptations and/or modifications as come withinthe scope of the following claims and their equivalents.

1. A composition for use in treating wrinkles, comprising emu oil andone or more additional anti-wrinkle agents.
 2. The composition of claim1, wherein the one or more anti-wrinkle agents are selected from thegroup consisting of All Trans Retinol, Retinyl palmitate, AcetylHexapeptide-3, Acetyl Glutamyl Heptapeptide, Palmitoyl Pentapeptide-3,Palmitoyl Oligopeptide, Palmitoyl Terapeptide-3, Dimethylaminoethanol(DMAE), Idebenone, Ubiquinone, an Alpha Hydroxy Acid (AHA), a BetaHydroxy Acid, salicylic acid, Kojic acid, niacinamide, nicotinic acid,5-octanoyl salicylic acid, heptyloxy 4 salicylic acid, 4-methoxysalicylic acid; sulfur-containing D and L amino acids and salts thereof,N-acetyl-L-cysteine; thiols, phytic acid, lipoic acid; lysophosphatidicacid; skin peel agents; Actein 27-Deoxyactein Cimicifugoside; adapalene;ademethionine; adenosine; aletris extract; alkyl glutathione esters;alkoxyalkoxy alkoxyn benzoic; aloe derived lectins; amino propanephosphoric acid; 3-aminopropyl dihydrogen phosphate; Amadorine; aniseextracts; AOSINE; arginine amino benzoate; ASC III, ascorbyl palmitate;asiatic acid; asiaticosides; ARLAMOL GEO™; azaleic acid; benzoic acidderivatives; bertholletia extracts; betulinic acid; Biochanin A,Biopeptide Cl; Biopeptide EL; biotin; blackberry bark extract;blackberry lily extracts; black cohosh extract; blue cohesh extract;butanoyl betulinic acid; carboxymethyl 1,3 beta glucan; catecholamines;chalcones; citric acid esters; chaste tree extract; clover extracts;coumestrol; CPC Peptide; daidzein; dang gui extract; darutoside; debromolaurinterol; 1-decanoyl-glycero-phosphonic acid; dehydrocholesterol;dehydrodicreosol; dehydrodieugenol; dehydroepiandersterone;dermolectine; dehydroascorbic acid; dehydroepiandersterone sulfate;dianethole; hydroxy benzoic acid; 2,4 dihydroxybenzoic acid; diglycolguanidine succinate; diosgenin; disodium ascorbyl phosphate;dodecanedioic acid; ederline; enderline; equol; eriodictyol; estrogen;etf; ethocyn; eleseryl SH; endonucleine; ergosterol; eythrobic acid;fennel extract; fenugreek seed extract; fibrastil; fibrostimulines S andP; firmogen lS 8445; formononetin; forsythia fruit extract; gallic acidesters; gamma amino butyric acid; gatuline RC; genistein; genisteine;genistic acid; gentisyl alcohol; gingko bilboa extracts; ginsengextracts; ginsenoside; gluco pyranosyl-l-ascorbate; glutathione andesters thereof; glycitein; hesperitin; hexahydro curcumin; HMG-coenzymeA reductase inhibitors; hops extracts; 11 hydroxy undecanoic acid; 10hydroxy decanoic acid; 25-hydroxycholesterol; 7-hydroxylated sterols;hydroxyethyl isostearyloxy isopropanolamine; hydroxy-tetra methylpiperidinyloxy; hypotaurine; ibukijakou extract; isoflavone SG 10;kinetin; kohki extract; 1-2-oxo-thiazolidine-4-carboxylic acid esters;lactate dehydrogenase inhibitors; 1-lauryl,-lyso-phosphatidyl choline;lectins; lichochalcone LF15, licorice extracts; lignan; lumisterol;lupenes; luteolin; lysophosphitidic acid; magnesium ascorbyl phosphate;margin; melatonin; melibiose; metalloproteinase inhibitors; methoprene;methoprenic acid; mevalonic acid; MPC complex; N-methyl serine; N-methyltaurine; N,N-1-bis(lactyl) cysteamin; naringenin; neotigogenin;o-desmethylangoiensin; oat beta glucan; oleanolic acid; pantethine;phenylalanine; photoanethone; piperidine; placental extracts;pratensein; pregnenolone; pregnenolone acetate; pregnenolone succinate;premarin; quillaic acid; raloxifene; repair factor 1 and repair factorFCP; retinoates; retinyl glucuronate; retinyl linoleate; s-carboxymethylcysteine; seanamine fp; sodium ascorbyl phosphate; soya extracts; spleenextracts; tachysterol; taurine; tazarotene; tempol; thymulen; thymusextracts; thyroid hormones; tigogenin; tocopheryl retinoate; toxifolin;traumatic acid; tricholine citrate; trifoside; uracil derivatives;ursolic acid; vitamin D3 and its analogs; vitamin K; vitex extract; yamextract; yamogenin; zeatin; and mixtures thereof.
 3. The composition ofclaim 1, wherein the alpha hydroxyl acid is selected from the groupconsisting of glycolic acid, lactic acid, malic acid, and tartaric acid.4. The composition of claim 1, further comprising one or more additionalcomponents selected from the group consisting of vitamins,preservatives, antioxidants; free radical scavengers; depigmentationagents; reflectants; antimicrobial agents; allergy inhibitors;anti-aging agents; anti-wrinkling agents, antiseptics; analgesics;anti-inflammatory agents; fresheners; healing agents; anti infectives;inflammation inhibitors; vasoconstrictors; vasodilators; wound healingpromoters; peptides, polypeptides, proteins; skin lightening agents;antifungals; counterirritants; make-up preparations; vitamins; aminoacids and their derivatives; herbal extracts; flavoids; sensory markers;skin conditioners; chelating agents; cell turnover enhancers; nourishingagents; moisture absorbers; sebum absorbers; skin penetration enhancers,water, PEG-4, Aloe barbadensis leaf juice, onion bulb extract, xanthangum, allantoin, methylparaben, and sorbic acid.
 5. The composition ofclaim 1, further comprising one or more additional components selectedfrom the group consisting of fragrances, flavors, and botanicalextracts.
 6. The composition of claim 5, wherein the botanical extractis selected from the group consisting of oak bark extract, walnutextract, tincture of arnica, hamamelis extract, ribwort extract, pansyextract, thyme or sage extract; for the treatment of damaged or injuredskin, for example, St. John's wort tincture, cone flowers tincture,chamomile flowers extract, or calendula flowers tincture; and for thecare of exhausted and damaged skin, for example, birch leaves extract,nettle extract, coldsfoot extract, comfrey tincture, horsetail extract,and aloe vera extract.
 7. The composition of claim 4, wherein thepreservative is selected from the group consisting of alkyl esters ofpara-hydroxybenzoic acid, hydantoin derivatives, propionate salts, andquaternary ammonium compounds.
 8. The composition of claim 4, whereinthe preservative is selected from the group consisting of methylparaben,imidazolidinyl urea, sodium dehydroacetate, propylparaben, trisodiumethylenediamine tetraacetate (EDTA), and benzyl alcohol.
 9. Thecomposition of claim 4, wherein the vitamin is selected from the groupconsisting of vitamin A and derivatives thereof, vitamin B2, biotin,pantothenic acid, vitamin K, vitamin D, vitamin E and mixtures thereof.10. The composition of claim 1, further comprising one or moreadditional components selected from the group consisting ofantimicrobials, antifungals, and anti-inflammatories.
 11. A method fortreating wrinkles, comprising administering a composition of claim 1 toa patient in need of treatment thereof.
 12. The method of claim 11,wherein the one or more anti-wrinkle agents are selected from the groupconsisting of All Trans Retinol, Retinyl palmitate, AcetylHexapeptide-3, Acetyl Glutamyl Heptapeptide, Palmitoyl Pentapeptide-3,Palmitoyl Oligopeptide, Palmitoyl Terapeptide-3, Dimethylaminoethanol(DMAE), Idebenone, Ubiquinone, an Alpha Hydroxy Acid (AHA), a BetaHydroxy Acid, salicylic acid, Kojic acid, niacinamide, nicotinic acid,5-octanoyl salicylic acid, heptyloxy 4 salicylic acid, 4-methoxysalicylic acid; sulfur-containing D and L amino acids and salts thereof,N-acetyl-L-cysteine; thiols, phytic acid, lipoic acid; lysophosphatidicacid; skin peel agents; Actein 27-Deoxyactein Cimicifugoside; adapalene;ademethionine; adenosine; aletris extract; alkyl glutathione esters;alkoxyalkoxy alkoxyn benzoic; aloe derived lectins; amino propanephosphoric acid; 3-aminopropyl dihydrogen phosphate; Amadorine; aniseextracts; AOSINE; arginine amino benzoate; ASC III, ascorbyl palmitate;asiatic acid; asiaticosides; ARLAMOL GEO™; azaleic acid; benzoic acidderivatives; bertholletia extracts; betulinic acid; Biochanin A,Biopeptide Cl; Biopeptide EL; biotin; blackberry bark extract;blackberry lily extracts; black cohosh extract; blue cohesh extract;butanoyl betulinic acid; carboxymethyl 1,3 beta glucan; catecholamines;chalcones; citric acid esters; chaste tree extract; clover extracts;coumestrol; CPC Peptide; daidzein; dang gui extract; darutoside; debromolaurinterol; 1-decanoyl-glycero-phosphonic acid; dehydrocholesterol;dehydrodicreosol; dehydrodieugenol; dehydroepiandersterone;dermolectine; dehydroascorbic acid; dehydroepiandersterone sulfate;dianethole; hydroxy benzoic acid; 2,4 dihydroxybenzoic acid; diglycolguanidine succinate; diosgenin; disodium ascorbyl phosphate;dodecanedioic acid; ederline; enderline; equol; eriodictyol; estrogen;etf; ethocyn; eleseryl SH; endonucleine; ergosterol; eythrobic acid;fennel extract; fenugreek seed extract; fibrastil; fibrostimulines S andP; firmogen lS 8445; formononetin; forsythia fruit extract; gallic acidesters; gamma amino butyric acid; gatuline RC; genistein; genisteine;genistic acid; gentisyl alcohol; gingko bilboa extracts; ginsengextracts; ginsenoside; gluco pyranosyl-l-ascorbate; glutathione andesters thereof; glycitein; hesperitin; hexahydro curcumin; HMG-coenzymeA reductase inhibitors; hops extracts; 11 hydroxy undecanoic acid; 10hydroxy decanoic acid; 25-hydroxycholesterol; 7-hydroxylated sterols;hydroxyethyl isostearyloxy isopropanolamine; hydroxy-tetra methylpiperidinyloxy; hypotaurine; ibukijakou extract; isoflavone SG 10;kinetin; kohki extract; 1-2-oxo-thiazolidine-4-carboxylic acid esters;lactate dehydrogenase inhibitors; 1-lauryl,-lyso-phosphatidyl choline;lectins; lichochalcone LF15, licorice extracts; lignan; lumisterol;lupenes; luteolin; lysophosphitidic acid; magnesium ascorbyl phosphate;margin; melatonin; melibiose; metalloproteinase inhibitors; methoprene;methoprenic acid; mevalonic acid; MPC complex; N-methyl serine; N-methyltaurine; N,N-1-bis(lactyl) cysteamin; naringenin; neotigogenin;o-desmethylangoiensin; oat beta glucan; oleanolic acid; pantethine;phenylalanine; photoanethone; piperidine; placental extracts;pratensein; pregnenolone; pregnenolone acetate; pregnenolone succinate;premarin; quillaic acid; raloxifene; repair factor 1 and repair factorFCP; retinoates; retinyl glucuronate; retinyl linoleate; s-carboxymethylcysteine; seanamine fp; sodium ascorbyl phosphate; soya extracts; spleenextracts; tachysterol; taurine; tazarotene; tempol; thymulen; thymusextracts; thyroid hormones; tigogenin; tocopheryl retinoate; toxifolin;traumatic acid; tricholine citrate; trifoside; uracil derivatives;ursolic acid; vitamin D3 and its analogs; vitamin K; vitex extract; yamextract; yamogenin; zeatin; and mixtures thereof.